Background: Migraine is characterized by multiple attacks of severe headaches often unilateral. The molecular mechanisms of migraine have not yet been clearly defined. Disorders of oxidant-antioxidant balance are observed in a number of acute and chronic diseases of the central nervous system. Oxidative stress is also believed to play a role in the pathogenesis of migraine. To the best of our knowledge, this is the first study investigating oxidant and antioxidant status of patients having migraine without aura (MWoA) and comparing them with those of age and sex matched healthy controls (CG).