Prediction of class I T-cell epitopes: evidence of presence of immunological hot spots inside antigens

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Srinivasan K. N., Zhang G. L., KHAN M. A., August J. T., Brusic V.

BIOINFORMATICS, vol.20, pp.297-302, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2004
  • Doi Number: 10.1093/bioinformatics/bth943
  • Journal Name: BIOINFORMATICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.297-302
  • Bezmialem Vakıf University Affiliated: No


Motivation: Processing and presentation of major histocompatibility complex class I antigens to cytotoxic T-lymphocytes is crucial for immune surveillance against intracellular bacteria, parasites, viruses and tumors. Identification of antigenic regions on pathogen proteins will play a pivotal role in designer vaccine immunotherapy. We have developed a system that not only identifies high binding T-cell antigenic epitopes, but also class I T-cell antigenic clusters termed immunological hot spots.