Prediction of class I T-cell epitopes: evidence of presence of immunological hot spots inside antigens

Srinivasan, K.; Zhang, G.; KHAN, MOHAMMAD; August, J.; Brusic, V.

doi:10.1093/bioinformatics/bth943

Prediction of class I T-cell epitopes: evidence of presence of immunological hot spots inside antigens

Srinivasan K. N., Zhang G. L., KHAN M. A., August J. T., Brusic V.

BIOINFORMATICS, cilt.20, ss.297-302, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20
Basım Tarihi: 2004
Doi Numarası: 10.1093/bioinformatics/bth943
Dergi Adı: BIOINFORMATICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.297-302
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Motivation: Processing and presentation of major histocompatibility complex class I antigens to cytotoxic T-lymphocytes is crucial for immune surveillance against intracellular bacteria, parasites, viruses and tumors. Identification of antigenic regions on pathogen proteins will play a pivotal role in designer vaccine immunotherapy. We have developed a system that not only identifies high binding T-cell antigenic epitopes, but also class I T-cell antigenic clusters termed immunological hot spots.