Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes


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Zhang G. L. , KHAN M. A. , Srinivasan K. N. , Heiny A. T. , Lee K. X. , Kwoh C. K. , ...More

BMC BIOINFORMATICS, vol.9, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2008
  • Doi Number: 10.1186/1471-2105-9-s1-s19
  • Title of Journal : BMC BIOINFORMATICS

Abstract

Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherapies because they are relevant to a large proportion of the human population. The presence of clusters of promiscuous T-cell epitopes, immunological hotspots, has been observed in several antigens. These clusters may be exploited to facilitate the development of epitope-based vaccines by selecting a small number of hotspots that can elicit all of the required T-cell activation functions. Given the large size of pathogen proteomes, including of variant strains, computational tools are necessary for automated screening and selection of immunological hotspots.