Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability

Tan P. T., KHAN M. A., August J. T.

HUMAN VACCINES, cilt.7, sa.4, ss.402-409, 2011 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 7 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4161/hv.7.4.13845
  • Dergi Adı: HUMAN VACCINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.402-409
  • Anahtar Kelimeler: T cell epitopes-based vaccine, pan-influenza, immunoinformatics, altered peptide ligands, high conservation, immunodominance, pandemic H1N1, MHC CLASS-II, VIRUS PB1 PROTEIN, IN-VITRO, IMMUNODOMINANCE HIERARCHIES, ANTIGENIC DRIFT, CTL EPITOPES, PA SUBUNIT, HLA-DR, RESPONSES, NUCLEOPROTEIN
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Vaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as potential T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains.