Clinical outcome in children with Henoch-Schonlein nephritis

Mir S., Yavascan O., Mutlubas F., Yeniay B., Sonmez F.

PEDIATRIC NEPHROLOGY, vol.22, no.1, pp.64-70, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1007/s00467-006-0278-0
  • Journal Name: PEDIATRIC NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.64-70
  • Keywords: Henoch-Schonlein purpura, childhood, outcome, LONG-TERM PROGNOSIS, PURPURA NEPHRITIS, CLINICOPATHOLOGICAL CORRELATIONS, FOLLOW-UP, CHILDHOOD, FEATURES, ADULTS, RISK
  • Bezmialem Vakıf University Affiliated: No

Abstract

Henoch-Schonlein purpura (HSP) is the most common vasculitis in childhood. The long-term prognosis is variable and depends on renal involvement. The aim of this study was to evaluate both clinical features of the children with HSP and the prognoses of short- and long-term outcome of patients diagnosed as HSP nephritis (HSN). This is a retrospective data study of all children with HSP hospitalized from January 1991 to December 2005. The patients with HSN were classified according to their initial presentation, histologic findings, type of treatment and clinical outcome. All patients have been evaluated once every 2 months. Fifty-three of the patients had kidney biopsies. The patient population consisted of 141 children included 78 boys (55.3%) and 63 girls (44.7%) ranging in age at disease onset from 2 to 17 (8.9 +/- 3.29) years. Renal involvement was determined in 58.1%. Nephrotic and/or nephritic syndrome were found to be an unfavorable predictor both for short and long-term outcome (P < 0.05). However, 35% of these patients and 62% of them showed complete remission after 6 months and long-term course. Overall prognosis of HSN is relatively good and long-term morbidity is predominantly associated with initial presentation and renal involvement.