Evaluating the effectiveness of anti-tuberculosis treatment by detecting Mycobacterium tuberculosis 85B messenger RNA expression in sputum

Atahan E., Saribas S., Demirci M., Babalık A., Akkus S., Balıkcı A., ...More

Journal of Infection and Public Health, vol.13, pp.1490-1494, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jiph.2020.05.016
  • Journal Name: Journal of Infection and Public Health
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1490-1494
  • Keywords: 85B mRNA, Mycobacterium tuberculosis, Anti-tuberculosis treatment, PCR, STABILITY, SURROGATE, MARKER, DNA
  • Bezmialem Vakıf University Affiliated: Yes


Background: The antigen 85 complex (85B) is secreted in large quantities from growing mycobacteria and the presence of bacterial mRNA is an indicator of cell viability. The quantitative detection of 85B mRNA expression levels can be used to assess the success of anti-tuberculosis treatment outcomes to detect viable mycobacteria cells. Therefore, we evaluated the levels of 85B mRNA of Mycobacterium tuberculosis strains in patients with pulmonary tuberculosis.