TERPENOIDS FROM SALVIA-SCLAREA


ULUBELEN A., TOPCU G. , ERIS C., SONMEZ U., KARTAL M. , KURUCU S., ...More

PHYTOCHEMISTRY, vol.36, no.4, pp.971-974, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 1994
  • Doi Number: 10.1016/s0031-9422(00)90474-6
  • Title of Journal : PHYTOCHEMISTRY
  • Page Numbers: pp.971-974
  • Keywords: SALVIA SCLAREA, LABIATAE, SESQUITERPENES, DITERPENES, TRITERPENES, FLAVONOIDS, ANTIMICROBIAL ACTIVITY, ABIETANE DITERPENOIDS

Abstract

From an acetone extract of the whole plant Salvia sclarea, seven known diterpenes, sclareol, manool, salvipisone, ferruginol, microstegiol, candidissiol and 7-oxoroyleanone, and two new ones, 2,3-dehydrosalvipisone and 7-oxoferruginol-18-al, as well as two sesquiterpenes, caryophyllene oxide ind spathulenol, alpha-amyrin, beta-sitosterol and the flavonoids apigenin, luteolin, 4'-methylapigenin, 6-hydroxyluteolin-6,7,3',4'-tetramethyl ether, 6-hydroxy apigenin-7,4'-dimethyl ether were obtained. The diterpenoids and the sesquiterpenoids were tested for antimicrobial activity against standard bacterial strains and a yeast. 2,3-Dehydrosalvipisone, sclareol, manool, 7-oxoroyleanone, spathulenol and caryophyllene oxide were found to be active against Staphylococcus aureus, the first and third compound against Candida albicans and the last compound against Proteus mirabilis.