Cardiac safety of ribociclib evaluated with 24-hour rhythm Holter electrocardiogram

Yasin A. I., ULUGANYAN M., Isleyen Z. S., Topcu A., Shbair A. T., ŞİMŞEK M., ...Daha Fazla

Supportive Care in Cancer, cilt.32, sa.8, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 8
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s00520-024-08702-0
  • Dergi Adı: Supportive Care in Cancer
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Cardiotoxicity, Holter ECG, Hormon-positive breast cancer, Ribociclib
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Objective: We aimed to evaluate cardiac safety profile of ribociclib with 24-h rhythm Holter ECG. Material and method: Forty-two female metastatic breast cancer patients were included in the study. Rhythm Holter ECG was performed before starting treatment with ribociclib and after 3 months of the treatment initiation. Results: The mean age of the patients was 56.36 ± 12.73. 52.4% (n = 22) of the patients were using ribociclib in combination with fulvestrant and 47.6% (n = 20) with aromatase inhibitors. None of the patients developed cardiotoxicity. When the rhythm Holter results before and in third month of the treatment were compared, there was no statistically significant difference. Conclusion: This is the first study evaluating effects of ribociclib treatment on cardiac rhythm with Holter ECG. The findings suggested ribociclib has a low risk of causing early cardiotoxicity.