Selective endothelin a (ETA) receptor antagonist (BQ-123) reduces both myocardial infarct size and oxidant injury


Ozdemir R. , Parlakpinar H., Polat A., ÇOLAK C., ERMİŞ N., Acet A.

TOXICOLOGY, vol.219, pp.142-149, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 219
  • Publication Date: 2006
  • Doi Number: 10.1016/j.tox.2005.11.022
  • Title of Journal : TOXICOLOGY
  • Page Numbers: pp.142-149

Abstract

Objective: Endothelins (ET) can be considered stress-responsive regulators working in paracrine and autocrine fashion. It has been suggested that elevated levels of ET may be responsible for the low coronary re-flow phenomena. Ischemia-reperfusion (I/R) was shown to stimulate ET release in rat heart; however, the mechanism(s) of this effect has not been clarified. Therefore, this study was focused to investigate the effect of BQ-123, selective ETA receptor antagonist, on three aspects of myocardial ischemia-reperfusion (MI/R) injury: hemodynamic parameters, infarct size and oxidant-antioxidant status in the absence and presence of ET-1 in an vivo rat model.