Effect of SARS-CoV-2 infection on out-of-hospital cardiac arrest outcomes – systematic review and meta-analysis

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Krawczyk A., Szarpak L., Bragazzi N. L., CANDER B., Feduniw S., Pruc M., ...More

Annals of Agricultural and Environmental Medicine, vol.30, no.2, pp.369-375, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.26444/aaem/167805
  • Journal Name: Annals of Agricultural and Environmental Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Environment Index, MEDLINE, Pollution Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.369-375
  • Keywords: COVID-19, infection, OHCA, out-of-hospital cardiac arrest, outcomes, SARS-CoV-2, survival rate
  • Bezmialem Vakıf University Affiliated: Yes


Introduction and Objective. The COVID-19 pandemic caused by the SARS-CoV-2 virus has recently presented the world with an unprecedented challenge. The purpose of this systematic review and meta-analysis is to investigate the relationship between SARS-CoV-2 infection and out-of-hospital cardiac arrest (OHCA) by comparing data from infected and non-infected individuals. The study adds to our understanding of the broader effects of the pandemic on public health and emergency care by examining the influence of COVID-19 on OHCA. Materials and method. A comprehensive systematic literature search was performed using PubMed, EMBASE, Scopus, Web of Science, the Cochrane Library and Google Scholar from 1 January 2020 – 24 May 2023. Incidence rates and odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs) for risk factors were recorded from individual studies, and random-effects inverse variance modelling used to generate pooled estimates. Results. Six studies, involving 5,523 patients, met the criteria for inclusion in the meta-analysis. Survival to hospital admission, defined as admission to the emergency department with sustained return of spontaneous circulation (ROSC), among patients with and without on-going infection was 12.2% and 20.1%, respectively (p=0.09). Survival to hospital discharge/30-day survival rate was 0.8% vs. 6.2% (p<0.001). Two studies reported survival to hospital discharge in good neurological condition; however, the difference was not statistically significant (2.1% vs. 1.8%; p=0.37). Conclusions. Compared to the non-infected patients, the ongoing SARS-CoV-2 infection was associated with worse OHCA outcomes.