Role of gut microbiota: Obesity and NAFLD

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GANGARAPU V., YILDIZ K., Ince A. T., BAYSAL B.

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.25, sa.2, ss.133-140, 2014 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/tjg.2014.7886
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.133-140
  • Anahtar Kelimeler: Non-alcoholic fatty liver disease, obesity, endotoxin, microbiota, FATTY LIVER-DISEASE, INTESTINAL BACTERIAL OVERGROWTH, DIET-INDUCED OBESITY, INDUCED INSULIN-RESISTANCE, GERM-FREE MICE, NONALCOHOLIC STEATOHEPATITIS, HEPATIC STEATOSIS, INNATE IMMUNITY, ENERGY-BALANCE, PLASMA-LEVELS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD.