The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes

Togar B., Turkez H., TATAR A., Kirkpinar İ., HACIMÜFTÜOĞLU A., GEYİKOĞLU F., ...More

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.28, no.4, pp.327-333, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1177/0748233711410919
  • Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.327-333
  • Keywords: Human lymphocytes, olanzapine, quetiapine, risperidone, single cell gel electrophoresis, micronucleus assay, PERIPHERAL-BLOOD LYMPHOCYTES, PROTECT PC12 CELLS, LIPID-PEROXIDATION, COMET ASSAY, IN-VITRO, SCHIZOPHRENIC-PATIENTS, ANTIOXIDANT ENZYMES, CLINICAL-RESPONSE, OXIDATIVE STRESS, OLANZAPINE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0-400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.