Investigation of Diagnostic Proteins by 2D Electrophoresis in Major Depression Model Induced by Forced Swim Test in Rats

Duman T., Akyüz E., Bulut H., Koçyiğit A., Tülek A., KarataŞ E., ...More

PROTEIN AND PEPTIDE LETTERS, vol.28, no.2, pp.195-204, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.2174/0929866527999200729183729
  • Journal Name: PROTEIN AND PEPTIDE LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.195-204
  • Keywords: Depression model, rats, 2D electrophoresis, protein, forcing swim test, major depression
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Aside from its pervasiveness, whereby it affects as much as 20% of the world's population, depression continues to be one of the most crucial psychiatric problems due to the loss of power it causes by disrupting daily life functioning, containing economic consequences, and having a high suicidal tendency. Major depression (MD) is a systemic and multifactorial disorder involving complex interactions between genetic predisposition and disturbances of various molecular pathways.