Solitary Breast Metastasis of the Lower Extremity Malignant Fibrous Histiocytoma: Report of a Case and Review of the Literature

Adli M., Turk H. M., Kalender M. E., Tutar E., Dirier A.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.29, no.5, pp.1320-1325, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2009
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1320-1325
  • Bezmialem Vakıf University Affiliated: Yes


Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in adults and its distant metastases most commonly occur in the lung, bone and liver. However, breast metastases of this tumor are extremely rare. A 67-year-old woman presented with a single left breast mass as the only metastasis two years after the initial surgery of the MFH of lower extremity. A mass had appeared below her right knee 32 months before she recognized her breast mass, and she had undergone surgery for it 8 months later. The patient is alive and disease-free 59 months after the lower leg surgery and 31 months after the breast surgery. Despite several reports of primary breast MFH cases, only three cases of breast metastasis have been reported in the literature. Breast metastases from extra mammary malignancies are also rare. However, no report of isolated breast metastasis is present in the medical literature. This is the first case of solitary breast metastasis of the MFH, reported with all clinical, radiological and histological details, in English literature to our. best knowledge. Malignant fibrous histiocytoma may present as a solitary breast metastasis as the first site of metastasis. Breast metastasis should be kept in mind in a patient with MFH diagnosis presenting with solitary breast mass.