Analysis of Chromosome 3, 7 and 8 Centromeric Regions in Bronchial Lavage Specimens by FISH

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Atasoy S., Erturan S. S., Yilmaz N., Kuru D., Cirakoglu A., Yilmaz S., ...More

TURKISH THORACIC JOURNAL, vol.17, no.4, pp.141-147, 2016 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.5578/ttj.30506
  • Journal Name: TURKISH THORACIC JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.141-147
  • Bezmialem Vakıf University Affiliated: No

Abstract

OBJECTIVES: Multiple genetic changes are observed in malignant tumors but are rare or absent in benign conditions. Aneuploidy is the most common feature of solid tumors including lung cancer and diagnosis of malignant tumors is possible through detection of aneuploidy. The aim of this study was to investigate chromosomal abnormalities in cells from non-small cell lung cancer patients obtained bronchoscopically and to evaluate the suitability of fluorescence in situ hybridization (FISH).