Treatment of chronic hepatitis B infection with IFN-alpha: Long term results and influence of delta superinfection

Senturk H., Mert A., TABAK Ö. F., Sander E., Akdogan M., Ozdemir S., ...Daha Fazla

10th Mediterranean Congress of Chemotherapy, Antalya, Türkiye, 20 - 25 Ekim 1996, ss.391-395, (Tam Metin Bildiri) identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası:
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.391-395
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

We aimed to evaluate the long-term effect of interferon-alfa(Ifh-alpha.) on chronic type B hepatitis. We treated 39 patients with Ifn-alpha 2a for 4-6 moths with various doses. The patients were followed-up for, at least, 18 months untreated:. Tell of 39(26%) were carrying antibodies against delta agent. In 14 of 29 delta negatives, HBeAg was present in circulation. The other 15 were HBV-DNA +ve, and HBeAg -ve. Five of 14(36%) HBe +ves, and 8 of 15(53%)HBe -ves responded. None of the 10 anti-delta +ves responded. 2/5(40%) from HBe + group, and 4/8(50%) from HBe -ve group relapsed. The overall sustained response rate was 21% in tile HBe +ve, and 27% in tile HBe -ve group. It was concluded that Ifn-alpha treatment achieves all overall sustained response rate of 24% in chronic type B hepatitis uncomplicated by delta agent. Patients with delta superinfection, invariably, do not respond to conventional treatment.