Close Association of AFP Level with HBVDNA Increase Caused by Lamivudine And Adefovir Resistance

Karaman Ö., Colbay M., Uslan I., Acarturk G.

MEDICAL JOURNAL OF BAKIRKOY, cilt.6, sa.1, ss.39-41, 2010 (ESCI, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2010
  • Dergi Adı: MEDICAL JOURNAL OF BAKIRKOY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.39-41
  • Anahtar Kelimeler: Alpha fetoprotein, chronic hepatitis B, lamivudine resistance, adefovir resistance, entecavir, SERUM ALPHA-FETOPROTEIN, HEPATOCELLULAR-CARCINOMA, DIAGNOSIS
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Marked elevations in serum alpha fetoprotein (AFP) levels are highly suspicious for hepatocellular carcinoma and should prompt an extensive diagnosis. We report a case of chronic hepatitis B where episodes of marked elevations in serum AFP levels occurred, after viral breakthrough and acute exacerbation of hepatitis following development of lamivudine and adefovir resistance. The patient had a prompt improvement after adefovir and entacavir treatment, respectively.