Close Association of AFP Level with HBVDNA Increase Caused by Lamivudine And Adefovir Resistance

Karaman Ö., Colbay M., Uslan I., Acarturk G.

MEDICAL JOURNAL OF BAKIRKOY, vol.6, no.1, pp.39-41, 2010 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2010
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.39-41
  • Keywords: Alpha fetoprotein, chronic hepatitis B, lamivudine resistance, adefovir resistance, entecavir, SERUM ALPHA-FETOPROTEIN, HEPATOCELLULAR-CARCINOMA, DIAGNOSIS
  • Bezmialem Vakıf University Affiliated: No


Marked elevations in serum alpha fetoprotein (AFP) levels are highly suspicious for hepatocellular carcinoma and should prompt an extensive diagnosis. We report a case of chronic hepatitis B where episodes of marked elevations in serum AFP levels occurred, after viral breakthrough and acute exacerbation of hepatitis following development of lamivudine and adefovir resistance. The patient had a prompt improvement after adefovir and entacavir treatment, respectively.