Losartan-induced hepatic injury

TABAK Ö. F., Mert A., Ozaras R., Biyikli M., Ozturk R., Ozbay G., ...Daha Fazla

JOURNAL OF CLINICAL GASTROENTEROLOGY, cilt.34, sa.5, ss.585-586, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 5
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1097/00004836-200205000-00022
  • Dergi Adı: JOURNAL OF CLINICAL GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.585-586
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare. We report a case of severe hepatic toxicity and fibrosis caused by losartan use, and we review four previously reported cases. Drug-induced hepatic injury may be seen during the treatment of hypertension by losartan and the clinician should be aware of this toxicity, especially during the initial phase of treatment.