Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

Ekmekci A., Uluganyan M., Tufan F., Uyarel H., Karaca G., Kul S., ...More

JOURNAL OF GERIATRIC CARDIOLOGY, vol.10, no.4, pp.310-316, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3969/j.issn.1671-5411.2013.04.002
  • Journal Name: JOURNAL OF GERIATRIC CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.310-316
  • Keywords: Admission hyperglycemia, Elderly patients, In-hospital mortality, Long-term mortality, Major adverse cardiac events, LONG-TERM MORTALITY, INSULIN-POTASSIUM INFUSION, LEFT-VENTRICULAR FUNCTION, DIABETES-MELLITUS, ACUTE HYPERGLYCEMIA, PLASMA-GLUCOSE, RANDOMIZED-TRIAL, RISK, THERAPY, STEMI
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events. We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients (> 65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction. Methods We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 +/- 5.4). Patients were divided into two groups according to admission blood glucose levels. Group 1: low glucose group (LLG), glucose < 168 mg/dL; and Group 2: high glucose group (HGG), glucose > 168 mg/dL. Results In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P < 0.001). Multivariate regression analysis showed: Killip > 1, post-thrombolysis in MI < 3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P < 0.001). Conclusions Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality.