Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

Ekmekci A., Uluganyan M. , Tufan F., Uyarel H., Karaca G., Kul S., ...More

JOURNAL OF GERIATRIC CARDIOLOGY, vol.10, no.4, pp.310-316, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3969/j.issn.1671-5411.2013.04.002
  • Page Numbers: pp.310-316
  • Keywords: Admission hyperglycemia, Elderly patients, In-hospital mortality, Long-term mortality, Major adverse cardiac events, LONG-TERM MORTALITY, INSULIN-POTASSIUM INFUSION, LEFT-VENTRICULAR FUNCTION, DIABETES-MELLITUS, ACUTE HYPERGLYCEMIA, PLASMA-GLUCOSE, RANDOMIZED-TRIAL, RISK, THERAPY, STEMI


Objective Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events. We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients (> 65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction. Methods We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 +/- 5.4). Patients were divided into two groups according to admission blood glucose levels. Group 1: low glucose group (LLG), glucose < 168 mg/dL; and Group 2: high glucose group (HGG), glucose > 168 mg/dL. Results In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P < 0.001). Multivariate regression analysis showed: Killip > 1, post-thrombolysis in MI < 3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P < 0.001). Conclusions Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality.