Sister chromatid exchange analysis in patients exposed to low dose of iodine-131 for thyroid scintigraphy


SONMEZ S. , IKBAL M., YILDIRIM M. Ş. , Gepdiremen A. A. , OZTAS S.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, vol.393, no.3, pp.259-262, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 393 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.1016/s1383-5718(97)00110-1
  • Title of Journal : MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
  • Page Numbers: pp.259-262

Abstract

To determine the genotoxic risk associated with diagnostic exposure to low doses of iodine 131 (I-131), sister chromatid exchange (SCE) analysis was performed in lymphocytes of 18 non-smoking women who received 370 kBq (10 mu Ci) intravenous I-131 sodium iodide as an adjuvant for scintigraphy for diagnosing thyroid nodularity. SCE frequencies were measured before and after I-131 administration. SCE results in the pre-treated phase were regarded as control. Although SCE values 24 h after I-131 administration did not show a significant increment (p > 0.05), there was a significant increase 72 h after treatment (p < 0.05). These results indicate that genetic damage might be induced by low dose of I-131. (C) 1997 Elsevier Science B.V.