Sister chromatid exchange analysis in patients exposed to low dose of iodine-131 for thyroid scintigraphy

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SONMEZ S., IKBAL M., YILDIRIM M. Ş., Gepdiremen A. A., OZTAS S.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, vol.393, no.3, pp.259-262, 1997 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 393 Issue: 3
• Publication Date: 1997
• Doi Number: 10.1016/s1383-5718(97)00110-1
• Journal Name: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.259-262
• Bezmialem Vakıf University Affiliated: No

Abstract

To determine the genotoxic risk associated with diagnostic exposure to low doses of iodine 131 (I-131), sister chromatid exchange (SCE) analysis was performed in lymphocytes of 18 non-smoking women who received 370 kBq (10 mu Ci) intravenous I-131 sodium iodide as an adjuvant for scintigraphy for diagnosing thyroid nodularity. SCE frequencies were measured before and after I-131 administration. SCE results in the pre-treated phase were regarded as control. Although SCE values 24 h after I-131 administration did not show a significant increment (p > 0.05), there was a significant increase 72 h after treatment (p < 0.05). These results indicate that genetic damage might be induced by low dose of I-131. (C) 1997 Elsevier Science B.V.