Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats

İLBEY Y. Ö., Ozbek E., Simsek A., Otunctemur A., ÇEKMEN M. B., Somay A.

FERTILITY AND STERILITY, vol.92, no.3, pp.1124-1132, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1016/j.fertnstert.2008.07.1758
  • Journal Name: FERTILITY AND STERILITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1124-1132
  • Keywords: Melatonin, cisplatin, cyclophosphamide, oxidative stress, antioxidant, testicular damage, testis, rat, INDUCED OXIDATIVE STRESS, INDUCED NEPHROTOXICITY, ACID, SPERMATOGENESIS, MUTAGENICITY, GLUTATHIONE, TOXICITY, LYCOPENE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: To evaluate the effect of melatonin on cyclophosphamide (CP)- and cisplatin-induced testicular toxicity with use of sperm parameters and biochemical and histopathologic approaches.