Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats

İLBEY, YUSUF; Ozbek, Emin; Simsek, Abdulmuttalip; Otunctemur, Alper; ÇEKMEN, MUSTAFA; Somay, Adnan

doi:10.1016/j.fertnstert.2008.07.1758

Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats

İLBEY Y. Ö., Ozbek E., Simsek A., Otunctemur A., ÇEKMEN M. B., Somay A.

FERTILITY AND STERILITY, cilt.92, sa.3, ss.1124-1132, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 92 Sayı: 3
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.fertnstert.2008.07.1758
Dergi Adı: FERTILITY AND STERILITY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1124-1132
Anahtar Kelimeler: Melatonin, cisplatin, cyclophosphamide, oxidative stress, antioxidant, testicular damage, testis, rat, INDUCED OXIDATIVE STRESS, INDUCED NEPHROTOXICITY, ACID, SPERMATOGENESIS, MUTAGENICITY, GLUTATHIONE, TOXICITY, LYCOPENE
Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Objective: To evaluate the effect of melatonin on cyclophosphamide (CP)- and cisplatin-induced testicular toxicity with use of sperm parameters and biochemical and histopathologic approaches.