Herbal Medicine for Glioblastoma:Current and Future Prospects.


Khan I. , Mahfooz S., Hatiboglu M. A.

Medicinal chemistry (Shariqah (United Arab Emirates)), vol.16, pp.1022-1043, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2020
  • Doi Number: 10.2174/1573406416666200130100833
  • Title of Journal : Medicinal chemistry (Shariqah (United Arab Emirates))
  • Page Numbers: pp.1022-1043
  • Keywords: Glioblastoma, chemoresistance, anticancer, phytochemicals, combination therapies, NF-KAPPA-B, IN-VITRO, CANCER-CELLS, ANTITUMOR-ACTIVITY, TINOSPORA-CORDIFOLIA, DOWN-REGULATION, ANEMONE-TAIPAIENSIS, SIGNALING PATHWAY, PERILLYL ALCOHOL, BOSWELLIC ACIDS

Abstract

Background: Glioblastoma is one of the most aggressive and devastating tumours of the central nervous system with short survival time. Glioblastoma usually shows fast cell proliferation and invasion of normal brain tissue causing poor prognosis. The present standard of care in patients with glioblastoma includes surgery followed by radiotherapy and temozolomide based chemotherapy. Unfortunately, these approaches are not sufficient to lead a favorable prognosis and survival rates. As the current approaches do not provide a long-term benefit in those patients, new alternative treatments including natural compounds, have drawn attention. Due to their natural origin, they are associated with minimum cellular toxicity towards normal cells and it has become one of the most attractive approaches to treat tumours by natural compounds or phytochemicals.