Herbal Medicine for Glioblastoma:Current and Future Prospects.

Khan I., Mahfooz S., Hatiboglu M. A.

Medicinal chemistry (Shariqah (United Arab Emirates)), vol.16, pp.1022-1043, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2020
  • Doi Number: 10.2174/1573406416666200130100833
  • Journal Name: Medicinal chemistry (Shariqah (United Arab Emirates))
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.1022-1043
  • Keywords: Glioblastoma, chemoresistance, anticancer, phytochemicals, combination therapies, NF-KAPPA-B, IN-VITRO, CANCER-CELLS, ANTITUMOR-ACTIVITY, TINOSPORA-CORDIFOLIA, DOWN-REGULATION, ANEMONE-TAIPAIENSIS, SIGNALING PATHWAY, PERILLYL ALCOHOL, BOSWELLIC ACIDS
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Glioblastoma is one of the most aggressive and devastating tumours of the central nervous system with short survival time. Glioblastoma usually shows fast cell proliferation and invasion of normal brain tissue causing poor prognosis. The present standard of care in patients with glioblastoma includes surgery followed by radiotherapy and temozolomide based chemotherapy. Unfortunately, these approaches are not sufficient to lead a favorable prognosis and survival rates. As the current approaches do not provide a long-term benefit in those patients, new alternative treatments including natural compounds, have drawn attention. Due to their natural origin, they are associated with minimum cellular toxicity towards normal cells and it has become one of the most attractive approaches to treat tumours by natural compounds or phytochemicals.