Effects of granulocyte macrophage colony stimulating factor on random flap healing and immune profile in rats with impaired wound healing by glucocorticoids


ERGUN S. , KYRAN B., Su O. , BILGIC B., YPSEVER H., KUCUK M.

ANNALS OF PLASTIC SURGERY, vol.52, no.1, pp.80-88, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1097/01.sap.0000096449.71981.1b
  • Title of Journal : ANNALS OF PLASTIC SURGERY
  • Page Numbers: pp.80-88

Abstract

Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling. Priming the tissue to be incised with proinflammatory cytokines offers a new approach to wound healing. This has been studied mostly in incisional wounds till now. This study was designed to investigate the role of granulocyte macrophage colony stimulating factor (GM-CSF) priming of planned incision lines in random flaps in rats with impaired wound healing due to glucocorticoid administration, and immune profiles of rats were also evaluated.