Effects of granulocyte macrophage colony stimulating factor on random flap healing and immune profile in rats with impaired wound healing by glucocorticoids


ERGUN S. , KYRAN B., Su O. , BILGIC B., YPSEVER H., KUCUK M.

ANNALS OF PLASTIC SURGERY, cilt.52, ss.80-88, 2004 (SCI İndekslerine Giren Dergi)

Özet

Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling. Priming the tissue to be incised with proinflammatory cytokines offers a new approach to wound healing. This has been studied mostly in incisional wounds till now. This study was designed to investigate the role of granulocyte macrophage colony stimulating factor (GM-CSF) priming of planned incision lines in random flaps in rats with impaired wound healing due to glucocorticoid administration, and immune profiles of rats were also evaluated.