Akademik Veri Yönetim Sistemi
International Conference on Herbs and Spices (ICHS - 2026), Rimini, İtalya, 21 - 23 Nisan 2026, ss.17, (Özet Bildiri)
The roots of Ferula L. species are commonly used as aphrodisiacs in traditional medicine in various
countries, including Türkiye. It is suggested in the literature that the major compound responsible for
the aphrodisiac effect in plants of the genus Ferula is ferutinin, a daucan-type sesquiterpene ester [1].
However, some species such as Ferula communis L. subsp. communis are known to be toxic due to
their prenylated coumarin content, such as ferulenol [2]. The study aimed to perform preliminary
comparative chemical analysis of Ferula elaeochytris Korovin and Ferula communis L. subsp.
communis ethanolic root extracts, with a focus on their ferutinin and ferulenol contents. Plant materials
were collected from their natural habitats in Türkiye. The ethanolic root extracts of the plants were
prepared. The ferutinin and ferulenol contents were determined by HPLC-PDA using calibration curves
created with the relative reference standards. According to the results of our study, 10.48±0.007%
ferutinin is detected in the extract of F. elaeochytris while ferulenol was not detected. In contrast, F.
communis subsp. communis extract did not contain ferutinin but contained 3.35±0.002% ferulenol.
Significant differences in chemical composition were observed between the two Ferula species. In
conclusion, the presence of ferulenol in F. communis subsp. communis extract indicates a potential
toxicological risk and may limit its suitability for biological activity studies. F. elaeochytris can be a
safer candidate due to its high ferutinin content and absence of detectable ferulenol. This study
represents a preliminary step prior to planned in vitro and in vivo investigations and it highlights the
importance of species identification and chemical profiling before biological and pharmacological
activity studies.