Treatment of coronavirus disease 2019: a comprehensive review


Sosyal D. , Özmen Ö. , Bektay M. Y. , İzzettin F. V.

Journal of Ideas in Health, vol.3, no.4, pp.228-242, 2020 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Review
  • Volume: 3 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.47108/jidhealth.vol3.iss4.71
  • Title of Journal : Journal of Ideas in Health
  • Page Numbers: pp.228-242

Abstract

The new type of Coronavirus
(
SARS
-
CoV
-
2
)
is a highly contagious pathogen that causes severe acute respiratory
syndrome and can be transmitted from human to human. COVID
-
19, which has been declared as a pandemic by the
world health organization and is infected with more than 50 million people, is
also responsible for the death of more
than 1 million people. There is no sufficient data from randomized clinical trials that any potential treatment improves
outcomes in COVID
-
19 patients. Chloroquine and hydroxychloroquine, antivirals such as
favipiravi
r,
lopinavir
/
r
itonavir,
immunomodulatory agents tocilizumab, siltuximab, and sarilumab, and anti
-
inflammatory drugs such as steroids are
used for the treatment of COVID
-
19. Repurposing drugs can provide new treatment options faster than
discovering
new drugs due to the known safety profiles of existing drugs. On the other hand, there are new drug and vaccine trials
for COVID
-
19. Many researchers, governmental or non
-
governmental institutions having clinical trials for COVID
-
19
drugs and v
accines. In this comprehensive review, we investigate the clinical features, management, and treatment of
COVID
-
19 and possible adverse effects and important information related to drugs used for COVID
-
19. For future
preparedness and readiness, new laws an
d legislations should be constituted. Besides, emergency teams and
budgets should be prepared as well.