Serum obestatin and omentin levels in patients with diabetic nephropathy

ZORLU M., KISKAC M., Gueler E. M., GUELTEPE I., YAVUZ E., CELIK K., ...More

NIGERIAN JOURNAL OF CLINICAL PRACTICE, vol.20, no.2, pp.182-187, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.4103/1119-3077.181350
  • Journal Name: NIGERIAN JOURNAL OF CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.182-187
  • Keywords: Diabetes mellitus type 2, diabetic nephropathy, obestatin, omentin, GHRELIN/OBESTATIN RATIO, CIRCULATING OMENTIN, INSULIN-RESISTANCE, METABOLIC SYNDROME, PLASMA OBESTATIN, GHRELIN, INFLAMMATION, MICROALBUMINURIA, ASSOCIATION, BIOMARKER
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Introduction: Diabetic nephropathy is the leading cause of chronic kidney disease and accounts for almost 45% of all new patients requiring renal replacement therapy. Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. Thus, we postulated that they may also have an association with diabetic nephropathy which is known to be an independent cardiovascular risk factor. In order to investigate such an association we compared serum omentin and obestatin levels in type 2 diabetic patients with normoalbuminuria (NA) and macroalbuminuria (MA).