Spontaneous Healing of Bilateral Brown Tumors in Mandible Via Treatment of Endocrine Disorder

Yücesoy T., Akkoyun E. F., Kılıç E., Doğruel F., Alkan A., Bayram F., ...More

AÇBİD- 10th International Congress- 2016, Antalya, Turkey, 11 - 15 May 2016, pp.262

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.262
  • Bezmialem Vakıf University Affiliated: Yes


The giant cell lesions associated with hyperparathyroidism are referred to as brown tumors. The diagnosis of brown tumor can be made through the use of biochemical tests such as serum calcium, alkaline phosphatase, phosphorus, sodium, potassium and parathyroid hormone levels in the presence of giant cell lesions. After the endocrine treatment these lesions can regress spontaneously. 24-year old man was referred to our department with bilateral swelling and spontaneous gingival bleeding from posterior of mandible. Intraoral examination revealed pericoronitis and spontaneous bleeding from periodontal pocket of right mandibular third molar, swelling in the bilateral retromolar regions. In radiographic examination, radiolucent well-demarcated lesions bilaterally in the mandibular third molar regions, measuring 4*3*3 cm on the right and 2,5*1,5*1,5 cm on the left, were observed. Brown tumor was suspected from his family history of endocrine disorder and biochemical tests demonstrated high level of serum calcium, alkaline phosphatase, parathyroid hormone. After consulting to endocrinology department, patient was hospitalized in the endocrinology clinic and further test were performed. After 2 months of endocrine therapy, bilateral regression of the lesions occurred spontaneously. In radiographic examination complete calcification of the lesions were observed after 6 months. There was no evidence of recurrence at 2 years. We report unusual case of brown tumor in the mandible that completely recovered after endocrine therapy. Because it is difficult to distinguish brown tumor from other giant cell lesions histopathologically, a clinical decision should be made with considering underlying systemic event. Surgical excision of brown tumor is not always necessary if the endocrine disorder is treated properly.