Research Information System
AÇBİD- 10th International Congress- 2016, Antalya, Turkey, 11 - 15 May 2016, pp.262
The giant cell lesions associated with hyperparathyroidism are referred to as brown tumors. The
diagnosis of brown tumor can be made through the use of biochemical tests such as serum calcium,
alkaline phosphatase, phosphorus, sodium, potassium and parathyroid hormone levels in the
presence of giant cell lesions. After the endocrine treatment these lesions can regress spontaneously.
24-year old man was referred to our department with bilateral swelling and spontaneous
gingival bleeding from posterior of mandible. Intraoral examination revealed pericoronitis
and spontaneous bleeding from periodontal pocket of right mandibular third molar,
swelling in the bilateral retromolar regions. In radiographic examination, radiolucent well-demarcated lesions bilaterally in the mandibular third molar regions, measuring 4*3*3 cm
on the right and 2,5*1,5*1,5 cm on the left, were observed. Brown tumor was suspected
from his family history of endocrine disorder and biochemical tests demonstrated high
level of serum calcium, alkaline phosphatase, parathyroid hormone. After consulting to
endocrinology department, patient was hospitalized in the endocrinology clinic and further
test were performed. After 2 months of endocrine therapy, bilateral regression of the
lesions occurred spontaneously. In radiographic examination complete calcification of the
lesions were observed after 6 months. There was no evidence of recurrence at 2 years.
We report unusual case of brown tumor in the mandible that completely recovered after
endocrine therapy. Because it is difficult to distinguish brown tumor from other giant cell
lesions histopathologically, a clinical decision should be made with considering underlying
systemic event. Surgical excision of brown tumor is not always necessary if the endocrine
disorder is treated properly.