Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in rats

KIZILAY A., KALCIOGLU M., OZEROL E., IRAZ M., GULEC M., AKYOL O., ...More

JOURNAL OF CHEMOTHERAPY, vol.16, no.4, pp.381-387, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1179/joc.2004.16.4.381
  • Journal Name: JOURNAL OF CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.381-387
  • Keywords: ototoxicity, cisplatin, antioxidant agents, caffeic acid phenethyl ester, otoacoustic emissions, outer hair cells, rat, CORD ISCHEMIA/REPERFUSION INJURY, XANTHINE-OXIDASE ACTIVITY, RABBITS, PROPOLIS, CAPE, ANTIOXIDANTS, IMBALANCE, EXTRACT, AGENTS, TISSUE
  • Bezmialem Vakıf University Affiliated: No

Abstract

Caffeic acid phenethyl ester (CAPE), an active component of propolis, exhibits antioxidant properties. This experimental study was designed to determine the effect of CAPE on ototoxicity induced with cisplatin. Twenty-four adult Wistar albino rats were divided into four groups: cisplatin (n=6), saline (n=6), CAPE (n=6), and cisplatin plus CAPE (n=6). Rats were tested before and 5 days after cisplatin treatment with or without chemo protection. The Distortion Product Otoacoustic Emissions (DPOAEs) were elicited from the control and experimental animals utilizing the standard commercial Otoacoustic Emission (OAEs) apparatus. The animals in all groups were sacrificed under general anesthesia on the fifth day following last OAE measurements. For biochemical investigations, the blood samples were drawn from inferior vena cava.