Are There Any Systemic Effects of the Intratympanic Administration of Dexamethasone?

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Senturk E., Tugrul S., Yildirim Y. S., DOĞAN R., EREN S. B., ÖZTURAN O.

BEZMIALEM SCIENCE, vol.6, no.3, pp.186-190, 2018 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.14235/bs.2018.1943
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.186-190
  • Keywords: Inner ear diseases, intratympanic steroids, systemic effects, SENSORINEURAL HEARING-LOSS, INNER-EAR, CORTICOSTEROID PHARMACOKINETICS, FLUIDS
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Systemic absorption of steroids is reasonable because of the lipophilic nature of steroids and high vascularity of the middle ear mucosa. To date, however, of the clinical trials designed to investigate this subject, to the best of our knowledge, none has been based on objective methods. This study aims to demonstrate whether the intratympanic administration of dexamethasone has any systemic effects.