Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone


ÜSTÜNOVA S., KILIÇ A., Bulut H., Gurel-Gurevin E., ERİŞ A. H. , MERAL İ.

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, vol.104, pp.176-193, 2022 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 104
  • Publication Date: 2022
  • Doi Number: 10.1080/02772248.2022.2051509
  • Journal Name: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.176-193
  • Keywords: 900 MHz EMF, cognitive functions, hippocampus, oxidative stress, thymoquinone, NIGELLA-SATIVA, RADIOFREQUENCY RADIATION, COGNITIVE IMPAIRMENT, PHONE, BRAIN, PREVENTS, DAMAGE, INFLAMMATION, PARAMETERS, NEURONS

Abstract

The protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 +/- 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.