Dose and time dependent ototoxicity of aspartame in rats.

Ozturan O., Dogan R., TUGRUL S., Gedik O., SJOSTRAND A. P., Yildirim Y. S.

Acta oto-laryngologica, vol.137, no.4, pp.421-425, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1080/00016489.2016.1256498
  • Journal Name: Acta oto-laryngologica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.421-425
  • Keywords: ABR, aspartame, DPOAE, ototoxicity, SWEETENERS, SAFETY
  • Bezmialem Vakıf University Affiliated: Yes


Conclusion: Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased.