Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.

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Hafız A., Doğan R., Gucin Z., Ozer Ö. F., Yenigun A., Ozturan O.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, vol.29, no.11, pp.1249-1254, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.17219/acem/127682
  • Journal Name: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.1249-1254
  • Keywords: antioxidant, tongue cancer, antitumoral, pyrrolidine dithiocarbamate, 4-nitroquinoline 1-oxide, NF-KAPPA-B, CARCINOGENESIS, ACTIVATION, INHIBITION, EXPRESSION, DAMAGE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background. Tongue tumors, which are oropharyngeal tumors, are increasing in frequency. Pyrrolidine dithiocarbamate (PDTC) is a powerful antioxidant and antitumoral agent. Objectives. To evaluate the protective and therapeutic effects of PDTC in a tongue cancer model induced with 4-nitroquinoline 1-oxide (4-NQO).